Principles of chemotherapy

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About the course

This course is part of the RCOG Core Knowledge series.

Chemotherapy continues to have an increasing role in the modern management of gynaecological malignancy. This tutorial starts by providing trainees with an easy to understand, practical introduction to oncology and chemotherapy. There is a detailed explanation of the mechanism of action and the side-effect profile of all the chemotherapy drugs used to treat gynaecological cancer. Finally, there is a review of the role of chemotherapy in the management of epithelial ovarian cancer, germ cell ovarian cancer, endometrial cancer, uterine sarcoma, cervical, vulval and fallopian tube cancer. Completion of this tutorial will guarantee comprehensive knowledge of how chemotherapy is used to treat women with gynaecological malignancy.

Course overview Authors Audience Related guidelines

When you have completed this course you will be able to:

  • explain the meaning of commonly used oncology terms
  • perform an assessment of how suitable a person is for chemotherapy treatment
  • assess radiological response to chemotherapy
  • calculate the dose of chemotherapy (please not this is beyond the level required for the Part 2 MRCOG)
  • list the common toxicities of chemotherapy and explain how they are managed
  • describe the mode of action, side effects and administration of the main chemotherapy drugs used in gynaecological cancer
  • define the role of chemotherapy in epithelial ovarian, germ cell ovarian, endometrial, uterine sarcoma, cervical, vulval and fallopian tube cancer

Dr Rachel Jones (2016)

Consultant Medical Oncologist at Velindre Cancer Centre, Cardiff specialising in ovarian cancer.

This course is intended to help clinicians gain core knowledge for O&G training and the MRCOG examinations.

Royal College of Obstetricians and Gynaecologists. Targeted Therapies for the Management of Ovarian Cancer. Scientific Impact Paper No 12. London: RCOG; 2013.

National Institute for Health and Care Excellence. Ovarian Cancer: Recognition and Initial Management. CG122. NICE; 2011.

National Institute for Health and Care Excellence. Cervical Cancer and HPV. Clinical Knowledge Summaries. NICE; 2014 (updated 2022).

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